A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry-Reference-Cited by-同舟云学术

A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry

Published:2017 Issue: Volume:2017 Page:1-6
ISSN:2090-6560
Container-title:Case Reports in Hematology
language:en
Short-container-title:Case Reports in Hematology

Author:

Pennisi Martina¹^ORCID,Cesana Clara²,Cittone Micol Giulia¹,Bandiera Laura²,Scarpati Barbara²,Mancini Valentina¹,Soriani Silvia²,Veronese Silvio²,Truini Mauro²,Rossini Silvano²,Cairoli Roberto¹

Affiliation:

1. Division of Hematology, Niguarda Ca’ Granda Hospital, Milan, Italy

2. Department of Laboratory Medicine, Niguarda Ca’ Granda Hospital, Milan, Italy

Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with aggressive clinical course and poor prognosis. Diagnosis is based on detection of CD4+CD56+,CD123high, TCL-1+, and blood dendritic cell antigen-2/CD303+blasts, together with the absence of lineage specific antigens on tumour cells. In this report we present a case of BPDCN presenting with extramedullary and bone marrow involvement, extensively studied by flow cytometry and immunohistochemistry, who achieved complete remission after acute lymphoblastic leukemia like chemotherapy and allogeneic hematopoietic stem cell transplantation.

Publisher

Hindawi Limited

Subject

Cell Biology,Developmental Biology,Embryology,Anatomy

Link

http://downloads.hindawi.com/journals/crihem/2017/4984951.pdf

Reference33 articles.

1. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

2. Plasmacytoid Dendritic Cells

3. The multifaceted biology of plasmacytoid dendritic cells

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