Comparison of Gastric Cancer Risk Classifications Using Conventional and New Pepsinogen Criteria

Author:

Sasakabe Tae1ORCID,Obata Yuki2,Kawai Sayo1ORCID,Lin Yingsong1,Kikuchi Shogo1ORCID

Affiliation:

1. Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

2. College of Pharmacy, Kinjo Gakuin University, Nagoya, Aichi, Japan

Abstract

Background. New serum pepsinogen (PG) criteria have been shown to indicate more accurately infection with Helicobacter pylori (H. pylori). We sought to improve risk classification for gastric cancer by adopting the new PG criteria with the addition of an H. pylori antibody test. Methods. The study participants were 275 patients with gastric cancer and 275 apparently healthy controls from case–control study data. We cross-sectionally compared the results of gastric cancer risk classifications that were based on a combination of the new PG criteria (PG II ≥ 10 ng/mL or PG I/II ≤ 5) and an H. pylori antibody test with those that were based on a combination of the conventional criteria (PG I ≤ 70 ng/mL and PG I/PG II ≤ 3) and an H. pylori antibody test. Results. Applying the conventional criteria resulted in 89 controls being classified as low risk. Applying the new criteria resulted in 23 controls (bootstrapped 95% confidence intervals [CI]: 14, 32) being additionally classified as high risk. Eight patients with gastric cancer were classified as low risk using the conventional criteria; however, six of these patients were classified as high risk by the new criteria (bootstrapped 95% CI: 2, 11). Conclusions. Compared with the conventional criteria, the new PG criteria with H. pylori antibody reduced instances of gastric cancer cases being misclassified as low risk. These findings suggest that the new PG criteria may help identify individuals at high risk of developing gastric cancer.

Funder

Ministry of Health, Labour and Welfare

Publisher

Hindawi Limited

Subject

Gastroenterology,Hepatology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Circulating Proteins as Diagnostic Markers in Gastric Cancer;International Journal of Molecular Sciences;2023-11-29

2. Recent trends in Helicobacter pylori management: harnessing the power of AI and other advanced approaches;Beni-Suef University Journal of Basic and Applied Sciences;2023-09-02

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