Spectroscopic Characterization, In Vitro Cytotoxicity, and Antioxidant Activity of Mixed Ligand Palladium(II) Chloride Complexes Bearing Nucleobases-Reference-Cited by-同舟云学术

Spectroscopic Characterization, In Vitro Cytotoxicity, and Antioxidant Activity of Mixed Ligand Palladium(II) Chloride Complexes Bearing Nucleobases

Published:2014-04-01 Issue: Volume:2014 Page:1-7
ISSN:2356-7457
Container-title:Journal of Inorganic Chemistry
language:en
Short-container-title:Journal of Inorganic Chemistry

Author:

Tetteh Samuel¹^ORCID,Dodoo David K.¹,Appiah-Opong Regina²,Tuffour Isaac²^ORCID

Affiliation:

1. Department of Chemistry, University of Cape Coast, Cape Coast, Ghana

2. Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

Abstract

Mixed-ligand palladium(II) chloride complexes bearing the nucleobases, adenine (Ad), cytosine (Cyt), and guanine (Gua), have been synthesized and characterized by UV-vis spectrophotometric methods, magnetic susceptibility, molar conductivity, elemental analysis, FTIR, and 1H-NMR. The complexes were found to have the composition cis-[PdCl2(Gua)(Cyt)], cis-[PdCl2(Ad)(Cyt)], and cis-[PdCl2(Ad)(Gua)]. A four-coordinated square-planar geometry is proposed for these Pd(II) complexes based on magnetic evidence and electronic spectra. The complexes as well as the free nucleobase ligands were tested for their in vitro cytotoxicity on human promyelocytic leukemia (HL60) and human histiocytic leukemia (U937) cell lines. cis-[PdCl2(Ad)(Gua)] showed IC50 values of 11.29 ± 2.91 and 8.31 ± 1.44 μM against HL60 and U937, respectively, which was higher than that of the positive control (curcumin) against U937. The complexes also showed significant antioxidant activity when tested against 2,2-diphenyl-1-picrylhydrazylradical (DPPH).

Funder

Government of Ghana

Publisher

Hindawi Limited

Link

http://downloads.hindawi.com/archive/2014/586131.pdf

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