Development and Evaluation of a Novel Polymer Drug Delivery System Using Cromolyn-Polyamides-Disulfide using Response Surface Design

Abstract

The aim of this study was to employ nanoparticles as drug carriers. The research involved the design of cromolyn polyamide-disulfide nanocomposites to overcome the problem of frequent cromolyn doses and improve their properties. The cromolyn polyamide-disulfide samples were prepared using several amounts of cromolyn and sodium polyamide-disulfide polymer at different pH values. Analysis of variance (ANOVA) was performed to obtain the significant independent variables affecting the dependent response by using a $P$ value lower than 0.05. The nanocomposites produced were characterized using Fourier transform infrared (FTIR) spectroscopy and in vitro release. An FTIR test was used to evaluate the functional groups of cromolyn in nanocomposites, which indicated that the drug was encapsulated inside the polymer. All data indicated the presence of cromolyn in the nanocomposites. The release profile of nanocomposites was found to be sustained. Therefore, the outcome of this research project could be a starting point for further work to optimize and assess polyamide-disulfide polymers for delivering another drug.