SLC2A9 rs1014290 Polymorphism is Associated with Prediabetes and Type 2 Diabetes

Abstract

Purpose. To investigate the association of the A/G rs1014290 polymorphism in SLC2A9 with type 2 diabetes (T2DM) and prediabetes mellitus (pre-DM). Patients and Methods. We enrolled 1058 patients who attended the Hebei General Hospital, Shijiazhuang, Hebei Province, China. The patients underwent general testing and oral glucose tolerance tests and were divided into three groups: 352 patients newly diagnosed with T2DM, 358 patients with pre-DM, and 348 healthy controls. The single nucleotide polymorphism (SNP) was detected by ligase detection reactions. The χ2 test, one-way ANOVA, and binary logistic regression analysis were used to analyze the results. Results. In the T2DM group, the GG genotype frequency at the rs1014290 locus was significantly lower (14.8%) than it was in the healthy controls. Furthermore, the GG genotype group was associated with a reduced risk of T2DM in unadjusted and confounder-adjusted models compared with the risk in the AA genotype group. The G allele in the SLC2A9 rs1014290 locus decreased susceptibility to T2DM. In the pre-DM group, the GG and AG genotype groups had no significant correlation with the risk of pre-DM in any of the models. In the T2DM group, the uric acid level was significantly lower in the GG genotype group. In the T2DM and pre-DM groups, the HOMA-β levels were significantly higher in the GA ( $P<0.001$ ) and GG ( $P<0.001$ ) genotype groups than it was in the AA genotype group, and HOMA-IR was significantly lower in the GA ( $P<0.001$ ) and GG ( $P<0.001$ ) genotype groups than it was in the AA genotype group. Conclusion. The A/G (rs1014290) SNP in SLC2A9 is closely related to the occurrence and development of diabetes.