Cardioprotective Effect of the CompoundYangshenGranule in Rat Models with Acute Myocardial Infarction

Abstract

The protective effect of CompoundYangshenGranules was observed in myocardial infarction rat model. Rats were randomly divided into 6 groups: the model group, the control group (sham operated), the positive drug group, and small, medium, and large dosage of theYangshengranule groups, respectively. The rats in the 3Yangshengranule groups were orally administrated with 0.7 g/kg, 1.4 g/kg, and 2.8 g/kg for 7 consecutive days, whereas the rats of the positive drug group treated with 0.14 g/kg of Danshen Dropping Pills, and rats in the control and model groups orally administrated with saline. The rat model of acute myocardial infarction was established with ligation of coronary artery. Electrocardiograms at different time points, the blood rheology, myocardial enzymes, infarct size, and myocardial morphologic changes were measured. The results demonstrated that the granules could improve blood rheology, decrease st-segment of electrocardiograms and the activities of LDH and CK in serum, reduce myocardial infarction size, and alleviate myocardial histopathologic changes. In addition, the effect of the granules depended on the dose administrated orally. The results suggest that theYangshengranules could produce cardioprotection effect and have potential benefits in the prevention of ischemic heart disease.