One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG

Abstract

α-Aminophosphonates(4a-j)were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes(2a-j)by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded4a-jin good yields. All these compounds were found to exhibit moderate to good antimicrobial activity.