A Concise Review on the Use of Mesenchymal Stem Cells in Cell Sheet-Based Tissue Engineering with Special Emphasis on Bone Tissue Regeneration-Reference-Cited by-同舟云学术

A Concise Review on the Use of Mesenchymal Stem Cells in Cell Sheet-Based Tissue Engineering with Special Emphasis on Bone Tissue Regeneration

Published:2017 Issue: Volume:2017 Page:1-13
ISSN:1687-966X
Container-title:Stem Cells International
language:en
Short-container-title:Stem Cells International

Author:

Yorukoglu A. Cagdas¹,Kiter A. Esat¹,Akkaya Semih¹,Satiroglu-Tufan N. Lale²,Tufan A. Cevik³^ORCID

Affiliation:

1. Department of Orthopaedics and Traumatology, School of Medicine, Pamukkale University, Denizli, Turkey

2. Department of Forensic Medicine, Forensic Genetics Laboratory, and Department of Pediatric Genetics, School of Medicine, Ankara University, Ankara, Turkey

3. Department of Histology and Embryology, School of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey

Abstract

The integration of stem cell technology and cell sheet engineering improved the potential use of cell sheet products in regenerative medicine. This review will discuss the use of mesenchymal stem cells (MSCs) in cell sheet-based tissue engineering. Besides their adhesiveness to plastic surfaces and their extensive differentiation potential in vitro, MSCs are easily accessible, expandable in vitro with acceptable genomic stability, and few ethical issues. With all these advantages, they are extremely well suited for cell sheet-based tissue engineering. This review will focus on the use of MSC sheets in osteogenic tissue engineering. Potential application techniques with or without scaffolds and/or grafts will be discussed. Finally, the importance of osteogenic induction of these MSC sheets in orthopaedic applications will be demonstrated.

Publisher

Hindawi Limited

Subject

Cell Biology,Molecular Biology

Link

http://downloads.hindawi.com/journals/sci/2017/2374161.pdf

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