Affiliation:
1. Tissue Typing Centre, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia
Abstract
In the present study, HLA allele and haplotype frequencies were studied using the HLA data of 9277 Croatian unrelated individuals, typed using high-resolution methods for the HLA-A, -B, -C, and -DRB1 loci. The total numbers of observed alleles were 47 for HLA-A, 88 for HLA-B, 34 for HLA-C, and 53 for HLA-DRB1. HLA-A
02:01 (29.5%), B
51:01 (10.5%), C
04:01 (15.8%), and DRB1
16:01 (10.4%) were the most frequent alleles in the Croatian general population. The three most frequent haplotypes were HLA-A
01:01~C
07:01~B
08:01~DRB1
03:01 (4.7%), HLA-A
03:01~C
07:02~B
07:02~DRB1
15:01 (1.7%), and HLA-A
02:01~C
07:01~B
18:01~DRB1
11:04 (1.5%). Allele and haplotype frequencies were compared between national and regional data, and differences were observed, particularly in the North Croatia region. The data has potential use in refining donor recruitment strategies for national registries of volunteer hematopoietic stem cell donors, solid organ allocation schemes, and the design of future disease and anthropological studies.
Subject
Immunology,General Medicine,Immunology and Allergy
Cited by
1 articles.
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