Evaluation of Poly(Glycidyl Methacrylate) Nanocoating for Chiral Separation with Glu-β-CD as Chiral Selector in Capillary Electrophoresis-Reference-Cited by-同舟云学术

Evaluation of Poly(Glycidyl Methacrylate) Nanocoating for Chiral Separation with Glu-β-CD as Chiral Selector in Capillary Electrophoresis

Published:2021-09-09 Issue: Volume:2021 Page:1-6
ISSN:1687-4129
Container-title:Journal of Nanomaterials
language:en
Short-container-title:Journal of Nanomaterials

Author:

Xu Jin¹,Sun Xuecheng²,Sun Xiaodong³^ORCID,Lu Ye⁴^ORCID

Affiliation:

1. Department of Neurology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China

2. Research and Development Center of Microelectronics, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China

3. School of Medicine, Shanghai University, Shanghai 200444, China

4. Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University, Shanghai 200433, China

Abstract

In this paper, a capillary coated with poly(glycidyl methacrylate) nanoparticles (PGMA NPs) was prepared and applied to construct a capillary electrophoresis (CE) enantioseparation system with glucosyl-β-cyclodextrin (Glu-β-CD) as a chiral selector. The PGMA NP coating can be easily introduced through a simple ring-opening reaction. Two basic drugs were used as models to evaluate the separation performance of the PGMA coating. Under the optimal conditions selected, the separation of the two enantiomers was obtained.

Publisher

Hindawi Limited

Subject

General Materials Science

Link

http://downloads.hindawi.com/journals/jnm/2021/4145010.pdf

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