Cognitive and Emotional Impairment after Minor Stroke and Non-ST-Elevation Myocardial Infarction (NSTEMI): A Prevalence Study

Author:

Morsund Åse Hagen1ORCID,Ellekjær Hanne2,Gramstad Arne3,Reiestad Magnus Tallaksen4,Midgard Rune5ORCID,Sando Sigrid Botne6,Jonsbu Egil7,Næss Halvor8

Affiliation:

1. Department of Neurology, Møre and Romsdal Health Trust, Molde hospital, Molde and Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway

2. Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim and Stroke Unit, Department of Internal Medicine, St Olavs hospital, University Hospital of Trondheim, Norway

3. Department of Neurology, Haukeland University Hospital and Department of Biological and Medical Psychology, University of Bergen, Norway

4. Department of psychiatry, Møre and Romsdal Health Trust, Molde hospital, Molde, Norway

5. Department of Neurology, Møre and Romsdal Health Trust, Molde hospital, Molde and Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway

6. Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim and Department of neurology, St Olavs hospital, University Hospital of Trondheim, Norway

7. Department of Psychiatry, Møre og Romsdal Health Trust and Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway

8. Department of neurology, Haukeland University Hospital, Centre for age-related medicine, Stavanger University Hospital, Institute of Clinical Medicine, University of Bergen, Norway

Abstract

Aim. To study the prevalence of cognitive and emotional impairment following a minor ischemic stroke compared to an age-matched group with non-ST-elevation myocardial infarction (NSTEMI). Methods. We included patients aged 18-70 years with a minor ischemic stroke defined as modified Rankin Scale (mRS) 0-2 at day 7 or at discharge if before and age-matched NSTEMI patients with the same functional mRS. We applied a selection of cognitive tests and the patients completed a questionnaire comprising of Hospital Anxiety and Depression scale (HADS) and Fatigue Severity Scale (FSS) at follow-up 12 months after the vascular event. Results of cognitive tests were also compared to normative data. Results. 325 ischemic stroke and 144 NSTEMI patients were included. There was no significant difference in cognitive functioning between ischemic stroke and NSTEMI patients. Minor stroke patients and to a lesser extent NSTEMI patients scored worse on more complex cognitive functions including planning and implementation of activities compared to validated normative data. For the minor stroke patients the location of the ischemic lesion had no influence on the result. The prevalence of anxiety, depression, and fatigue was significantly higher in the stroke group compared to the NSTEMI group. Depression was independently associated with reduced cognitive function. Discussion and Conclusion. Minor ischemic stroke patients, and to lesser degree NSTEMI patients, had reduced cognitive function compared to normative data, especially executive functioning, on 12-month follow-up. The difference in cognitive function between stroke and NSTEMI patients was not significant. Depression was associated with low scores on cognitive tests highlighting the need to adequately address emotional sequelae when considering treatment options for cognitive disabilities.

Funder

Central Norway Regional Health Authority

Publisher

Hindawi Limited

Subject

Clinical Neurology

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