Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs

Author:

Ahmadi Neda1,Goldman Radoslav2,Seillier-Moiseiwitsch Françoise3,Noone Anne-Michelle3,Kosti Ourania2,Davidson Bruce J.1

Affiliation:

1. Department of Otolaryngology Head and Neck Surgery, Georgetown University Hospital, Washington, DC 20007, USA

2. Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA

3. Department of Biostatistics, Georgetown University Medical Center, Washington, DC 20057, USA

Abstract

We evaluated the chemopreventive effect of nonsteroidal anti-inflammatory drug (NSAID) use in head and neck squamous cell carcinomas (HNSCC) by conducting a case-control study based on the administration of a standardized questionnaire to 71 incident HNSCC cases and same number of healthy controls. NSAID use was associated with a 75% reduction in risk of developing HNSCC. A significant risk reduction was noted in association with frequency of NSAID use. Restricting the analysis to aspirin users revealed a significant 90% reduction in risk of developing HNSCC. This study provides evidence for a significant reduction in the risk of developing HNSCC in users of NSAIDs, and specifically aspirin users.

Funder

Flight Attendant Medical Research Institute

Publisher

Hindawi Limited

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