Role of Intracellular Ca2+and Na+/Ca2+Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury-Reference-Cited by-同舟云学术

Role of Intracellular Ca2+and Na+/Ca2+Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury

Published:2013 Issue: Volume:2013 Page:1-5
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Yang Dingping¹^ORCID,Yang Dingwei²^ORCID

Affiliation:

1. Division of Nephrology, Department of Internal Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China

2. Division of Nephrology, Department of Internal Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China

Abstract

The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood. Intracellular Ca2+overload is considered to be a key factor in CI-AKI. Voltage-dependent Ca2+channel (VDC) and Na+/Ca2+exchanger (NCX) system are the main pathways of intracellular Ca2+overload in pathological conditions. Here, we review the potential underlying mechanisms involved in CI-AKI and discuss the role of NCX-mediated intracellular Ca2+overload in the contrast media-induced renal tubular cell injury and renal hemodynamic disorder.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2013/678456.pdf

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