Sweetening Pharmaceutical Radiochemistry by18F-Fluoroglycosylation: A Short Review

Author:

Maschauer Simone1,Prante Olaf1ORCID

Affiliation:

1. Molecular Imaging and Radiochemistry, Department of Nuclear Medicine, Friedrich Alexander University, Schwabachanlage 6, 91054 Erlangen, Germany

Abstract

At the time when the highly efficient [18F]FDG synthesis was discovered by the use of the effective precursor 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (mannose triflate) for nucleophilic18F-substitution, the field of PET in nuclear medicine experienced a long-term boom. Thirty years later, various strategies for chemoselective18F-labeling of biomolecules have been developed, trying to keep up with the emerging field of radiopharmaceutical sciences. Among the new radiochemical strategies, chemoselective18F-fluoroglycosylation methods aim at the sweetening of pharmaceutical radiochemistry by providing a powerful and highly valuable tool for the design of18F-glycoconjugates with suitablein vivoproperties for PET imaging studies. This paper provides a short review (reflecting the literature not older than 8 years) on the different18F-fluoroglycosylation reactions that have been applied to the development of various18F-glycoconjugate tracers, including not only peptides, but also nonpeptidic tracers and high-molecular-weight proteins.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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