The Role ofγδT Cells in Systemic Lupus Erythematosus

Author:

Wu Meng1,Yang Jinhua1,Li Xiaofeng1,Chen Junwei1

Affiliation:

1. Department of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, China

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the overproduction of autoantibodies against an array of nuclear and cytoplasmic antigens and affects multiple organs, such as the skin, joints, kidneys, and neuronal tissues. T cells have been recognized as important players in the development of SLE due to their functions in cytokine secretion, antigen presentation, and supporting B cells for antibody production.γδT cells are a minor population of T cells that play important roles in infection and tumor-associated disease. In recent years, the role ofγδT cells in autoimmune diseases has been investigated. In this review, we discussed the role ofγδT cells in the pathogenesis of SLE.

Funder

Scientific and Technological Project in Shanxi Province

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

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