High Prevalence of Serum Immunoglobulin G Antibody toHelicobacter pyloriand Raised Serum Gastrin and Pepsinogen Levels in Enlarged Fold Gastritis

Abstract

To clarify the prevalence ofHelicobacter pyloriinfection in enlarged fold gastritis, serum immunoglobulin (Ig) G antibody toH pyloriwas determined in 19 patients with severely enlarged gastric body folds (the widest fold greater than 10 mm on the radiograph), 55 patients with moderately enlarged folds (6 to 10 mm) and 44 control subjects (5 mm or less). The prevalence of serum IgG antibody toH pyloriin the severe (100%) and moderate groups (100%) was significantly higher than that in controls (34.1%) (PÃ0.01). There were significant differences among the three groups in serum gastrin, pepsinogen I and pepsinogen II levels (severe had the highest levels, followed by moderate and then controls, PÃ0.001).H pyloricolonization in the gastric mucosa was confirmed by culture, urease test or both, and inflammation by hematoxylin and eosin stain in the 25H pyloriseropositive patients who underwent endoscopy and biopsy. Results suggest thatH pyloriinfection is highly prevalent in enlarged fold gastritis. Further studies on enlarged fold gastritis andH pyloriinfection are needed.