PGD Synthase and PGD2in Immune Resposne-Reference-Cited by-同舟云学术

PGD Synthase and PGD2in Immune Resposne

Published:2012 Issue: Volume:2012 Page:1-6
ISSN:0962-9351
Container-title:Mediators of Inflammation
language:en
Short-container-title:Mediators of Inflammation

Author:

Joo Myungsoo¹,Sadikot Ruxana T.²³

Affiliation:

1. Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan 627-870, Republic of Korea

2. Department of Veterans Affairs, Jesse Brown VA Hospital, Chicago, IL 60612, USA

3. Section of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, M/C 719, Chicago, IL 60612, USA

Abstract

PGD2is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH2, a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH2to PGD2by PGD synthases (PGDSs). PGD2can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD2provide opportunities for development of novel therapeutic approaches for resistant infections and refractory inflammatory diseases. This paper highlights the role of PGD synthases and PGD2 in immune inflammatory response.

Funder

Ministry of Education Science and Technology

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

Link

http://downloads.hindawi.com/journals/mi/2012/503128.pdf

Reference63 articles.

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