MiR-100 rs1834306 A>G Increases Biliary Atresia Risk in Southern Han Chinese Children

Abstract

Background. Biliary atresia (BA) is a type of severe cholestatic childhood disease that may have a genetic component. miR-100 plays a key role in regulating cell apoptosis, proliferation, and inflammatory reactions. A single-nucleotide polymorphism in miR-100 has been proven to modulate susceptibility to various diseases. Methods. We conducted a case-control retrospective study to explore the correlation between miR-100 gene polymorphism (rs1834306 A>G) and biliary atresia susceptibility in 484 Chinese patients and 1445 matched control subjects. Results. Our results showed that rs1834306 A>G was correlated with a significantly increased risk for BA (GG vs. AA: $\text{adjusted}\text{odds}\text{ratio}\left(\text{OR}\right)=1.44$ , $95\%\text{confidence}\text{interval}\left(\text{CI}\right)=1.02–2.03$ , $p=0.041$ ; and GG vs. AA/AG: $\text{adjusted}\text{OR}=1.39$ , $95\%\text{CI}=1.02–1.89$ , $p=0.036$ ). Conclusions. Our results showed that the rs1834306 A>G polymorphism is associated with an increased risk for BA and contributes to BA susceptibility.