YCl3 Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats-Reference-Cited by-同舟云学术

YCl3 Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats

Published:2017 Issue: Volume:2017 Page:1-6
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Ding Yechun¹,Tian Yuantong¹,Zeng Zhaoyi¹,Shuai Ping²,Lan Haiying²,Zhu Xianshen²,Zhong Yi³,Wu Longhuo¹^ORCID,Fan Xiaona⁴^ORCID

Affiliation:

1. College of Pharmacy, Gannan Medical University, Ganzhou 341000, China

2. School of Basic Medicine, Gannan Medical University, Ganzhou 341000, China

3. The Third Affiliated Hospital, Gannan Medical University, Ganzhou 341000, China

4. Research Department, Gannan Medical University, Ganzhou 341000, China

Abstract

The pollutants rare earth elements (REEs) have posed great threats to human health. To investigate the cytotoxicity of yttrium (Y), a model that rats have free access to water containing YCl3 for 6 months is utilized. The results showed that YCl3 treatment promoted neuronal cell apoptosis by upregulating the proapoptotic factors Bax, caspase-3, Cyto c, and DAPK and by downregulating the antiapoptotic factors Bcl-2 and XIAP at both mRNA and protein levels. Conclusively, YCl3 exhibited cytotoxicity and promoted neuronal cell death by the induction of apoptotic pathways.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2017/2183658.pdf

Reference32 articles.

1. Uncovering the end uses of the rare earth elements

2. In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics

3. Hepatic arterial90Yttrium glass microspheres (Therasphere) for unresectable hepatocellular carcinoma: Interim safety and survival data on 65 patients