Silica-Coated Liposomes for Insulin Delivery

Author:

Dwivedi Neelam12,Arunagirinathan M. A.1,Sharma Somesh2,Bellare Jayesh1

Affiliation:

1. Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India

2. Piramal Life Sciences Limited, Research and Development Division, Mumbai 400063, India

Abstract

Liposomes coated with silica were explored as protein delivery vehicles for their enhanced stability and improved encapsulation efficiency. Insulin was encapsulated within the fluidic phosphatidylcholine lipid vesicles by thin film hydration at pH 2.5, and layer of silica was formed above lipid bilayer by acid catalysis. The presence of silica coating and encapsulated insulin was identified using confocal and electron microscopy. The native state of insulin present in the formulation was evident from Confocal Micro-Raman spectroscopy. Silica coat enhances the stability of insulin-loaded delivery vehicles. In vivo study shows that these silica coated formulations were biologically active in reducing glucose levels.

Funder

IIT Bombay

Publisher

Hindawi Limited

Subject

General Materials Science

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