Genetic Analysis and Follow-Up of 25 Neonatal Diabetes Mellitus Patients in China

Author:

Cao Bingyan1,Gong Chunxiu1,Wu Di1,Lu Chaoxia2,Liu Fang2,Liu Xiaojing3,Zhang Yingxian3,Gu Yi1,Qi Zhan4,Li Xiaoqiao1,Liu Min1,Li Wenjing1,Su Chang1,Liang Xuejun1,Feng Mei5

Affiliation:

1. Department of Pediatric Endocrinology and Genetic Metabolism, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China

2. Institute of Basic Medical Sciences, Peking Union Medical College, Beijing 100730, China

3. Department of Endocrinology and Genetic Metabolism, Zhengzhou Children’s Hospital, Zhengzhou 450053, China

4. Department of Pediatrics, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China

5. Department of Endocrinology, Shanxi Children’s Hospital, Taiyuan 030013, China

Abstract

Aims.To study the clinical features, genetic etiology, and the correlation between phenotype and genotype of neonatal diabetes mellitus (NDM) in Chinese patients.Methods.We reviewed the medical records of 25 NDM patients along with their follow-up details. Molecular genetic analysis was performed. We compared the HbA1c levels between PNDM group and infantile-onset T1DM patients.Results.Of 25 NDM patients, 18 (72.0%) were PNDM and 7 (28.0%) were TNDM. Among 18 PNDM cases, 6 (33.3%) had known KATP channel mutations (KATP-PNDM). There were six non-KATP mutations, five novel mutations, includingINS,EIF2AK3(n=2),GLIS3, andSLC19A2, one knownEIF2AK3mutation. There are twoABCC8mutations in TNDM cases and one paternal UPD6q24. Five of the six KATP-PNDM patients were tried for glyburide transition, and 3 were successfully switched to glyburide. Mean HbA1c of PNDM was not significantly different from infantile onset T1DM (7.2% versus 7.4%,P=0.41).Conclusion.PNDM accounted for 72% of NDM patients. About one-third of PNDM and TNDM patients had KATP mutations. The genetic etiology could be determined in 50% of PNDM and 43% of TNDM cases. PNDM patients achieved good glycemic control with insulin or glyburide therapy. The etiology of NDM suggests polygenic inheritance.

Publisher

Hindawi Limited

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

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