Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

Author:

Kumar Vikram1ORCID,Singh Desh Deepak1,Lakhawat Sudarshan Singh1,Yasmeen Nusrath1ORCID,Pandey Aishwarya2,Singla Rajeev K.34ORCID

Affiliation:

1. Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, Rajasthan, India

2. INRS, Eau Terre Environnement Research Centre, Québec, QC, Canada

3. Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

4. iGlobal Research and Publishing Foundation, New Delhi, India

Abstract

The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity is a complex metabolic disease with multiple pathophysiological clinical conditions as comorbidities are associated with obesity such as diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, and inflammation-based clinical conditions. In obese individuals, adipocyte cells increased the expression of leptin, angiotensin, adipocytokines, plasminogen activators, and C-reactive protein. Currently, options for treatment and lifestyle behaviors interventions are limited, and keeping a healthy lifestyle is challenging. Various types of phytochemicals have been investigated for antiobesity potential. Here, we discuss pathophysiology and signaling pathways in obesity, epigenetic regulations, regulatory mechanism, functional ingredients in natural antiobesity products, and therapeutic application of phytochemicals in obesity.

Funder

Amity University

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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