Affiliation:
1. Institute of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway
2. Department of Organ Transplantation, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway
Abstract
Impaired wound healing is a frequent problem in diabetes. Hyperglycemia may be
an operative mechanism, but a link between glycemic control and wound healing has
never been established. Wounds in db/db mice have been extensively studied.
This study was undertaken to see if plasma glucose was a predictor of wound healing.
An excisional wound was made (149 db/db mice). Wound closure was
studied versus metabolic variables. The animals were 11.8±0.2
weeks (mean ± standard error of the mean), obese (38.1±0.5 g), and hyperglycemic (fasting plasma glucose 21.0±0.7 mmol/L). Wound closure at day 13 was 30.1±1.6%. In linear mixed model analyses neither fasting plasma glucose
nor its change from start to end of experiment was a significant predictor of wound closure (β=0.15, P=0.07, 95% CI: −0.01 to 0.31 and β=0.06, P=0.5, 95% CI: −0.11 to 0.23, resp.). However, increase in body weight significantly and independently predicted wound closure (for weight change, β=0.22, P=0.008, 95% CI: 0.06 to 0.38). This study strongly suggests that
wound healing in db/db mice is independent of prevailing glycemia but
dependent on anabolic changes such as weight gain over time.
Funder
Norwegian Diabetes Association
Subject
General Economics, Econometrics and Finance
Cited by
5 articles.
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