Update on the Treatment of Metastatic Urothelial Carcinoma

Author:

Bukhari Nedal1ORCID,Al-Shamsi Humaid O.2,Azam Faisal1

Affiliation:

1. Department of Medical Oncology, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia

2. Associate Professor, University of Sharjah, Sharjah, UAE

Abstract

Platinum-based combination chemotherapy has been the standard of care in the first-line treatment of metastatic urothelial carcinoma (mUC). Treatment of metastatic disease following progression on platinum-based regimens has evolved significantly in the last few years. Clinical trials are currently ongoing to determine how best to use and sequence these treatments. In this minireview, we will review current first-line treatment options in both cisplatin fit and cisplatin unfit patients and advances in first- and second-line treatments including chemotherapy and immunotherapy. This review reports key findings from the clinical trials especially highlighting the importance of PD-1 and PD-L1 inhibitors in the treatment of bladder/urothelial carcinomas.

Publisher

Hindawi Limited

Subject

General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Medicine

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