Two Cases ofHelicobacter pylori-Negative Gastric Outlet Obstruction in Children

Abstract

Gastric outlet obstruction (GOO) in children is most commonly caused by idiopathic hypertrophic pyloric stenosis. Prior to proton pump inhibitors and H2 blockers, peptic ulcer disease (PUD) secondary toH. pyloriwas a cause of GOO. Both patients presented with a history of weight loss, vomiting, and abdominal pain. Their diagnosis of PUD and GOO was made by EGD and UGI.H. pyloritesting was negative for both on multiple occasions but still receivedH. pylorieradication therapy. Patient 1 after failing pharmaceutical management underwent surgery for definitive treatment. Patient 2 underwent six therapeutic pyloric dilations before undergoing surgery as definitive treatment. These cases suggest that GOO secondary to PUD occurs in the absence ofH. pyloriinfection and surgical management can provide definitive therapy.