Affiliation:
1. Department of Chemistry, Islamia University, Bahawalpur, Pakistan
2. Universita degli Studi, Dipartimento di Chimica, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, Florence 50121, Italy
Abstract
Some novel transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] complexes of substituted pyridine Schiff-bases
have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff-bases
act as deprotonated tridentate for the complexation reaction with Co(II), Ni(II) and Zn(II) ions. The new
compounds, possessing the general formula [M(L)2] where [M=Co(II), Cu(II), Ni(II) and Zn(II) and HL=HL1, HL2, HL3 and HL4] show an octahedral geometry. In order to evaluate the effect of metal ions upon
chelation, the Schiff bases and their complexes have been screened for antibacterial activity against the
strains such as Escherichia coli,Staphylococcus aureus, and Pseudomonas aeruginosa. The complexed
Schiff bases have shown to be more antibacterial against one more bacterial species as compared to
uncomplexed Schiff-bases.
Subject
Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology
Cited by
113 articles.
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