Next Generation Delivery System for Proteins and Genes of Therapeutic Purpose: Why and How?

Author:

Sharma Ashish Ranjan1ORCID,Kundu Shyamal Kumar2ORCID,Nam Ju-Suk1ORCID,Sharma Garima1ORCID,Priya Doss C. George3,Lee Sang-Soo1,Chakraborty Chiranjib14ORCID

Affiliation:

1. Institute for Skeletal Aging & Orthopedic Surgery, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea

2. Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida 203201, India

3. Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India

4. Department of Bioinformatics, School of Computer Sciences, Galgotias University, Greater Noida 203201, India

Abstract

Proteins and genes of therapeutic interests in conjunction with different delivery systems are growing towards new heights. “Next generation delivery systems” may provide more efficient platform for delivery of proteins and genes. In the present review, snapshots about the benefits of proteins or gene therapy, general procedures for therapeutic protein or gene delivery system, and different next generation delivery system such as liposome, PEGylation, HESylation, and nanoparticle based delivery have been depicted with their detailed explanation.

Funder

Ministry of Health & Welfare, Republic of Korea

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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