Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

Author:

Ciccone Marco Matteo1,Scicchitano Pietro1ORCID,Salerno Christian2,Gesualdo Michele1ORCID,Fornarelli Fara1ORCID,Zito Annapaola1ORCID,Filippucci Lucia3,Riccardi Roberta1ORCID,Cortese Francesca1ORCID,Pini Francesca4ORCID,Angrisani Lucia4,Di Mauro Antonio4ORCID,Schettini Federico4,Laforgia Nicola4

Affiliation:

1. Cardiovascular Disease Section, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy

2. Dipartimento di Medicina Traslazionale-Laboratorio Igiene ed Medicina Ambientale, University of Piemonte Orientale A. Avogadro, Via Duomo 6, 13100 Vercelli, Italy

3. Department of Cardiovascular Disease Rehabilitation, U.S.L.2, Via Guerra 21, 06127 Perugia, Italy

4. Neonatology and Neonatal Intensive Care Section, Department of Gynecology, Obstetrics and Neonatology, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy

Abstract

Aim. To evaluate the influence of selected maternal and neonatal characteristics on aorta walls in term, appropriately grown-for-gestational age newborns.Methods. Age, parity, previous abortions, weight, height, body mass index before and after delivery, smoking, and history of hypertension, of diabetes, of cardiovascular diseases, and of dyslipidemia were all assessed in seventy mothers. They delivered 34 males and 36 females healthy term newborns who underwent ultrasound evaluation of the anteroposterior infrarenal abdominal aorta diameter (APAO), biochemical profile (glucose, insulin, total cholesterol, HDL and LDL cholesterol, triglycerides, fibrinogen, and D-dimers homeostasis model assessment [HOMAIR]index), and biometric parameters.Results. APAO was related to newborn length (r=+0.36;P=0.001), head circumference (r=+0.37;P=0.001), gestational age (r=+0.40,P=0.0005), HOMA index (r=+0.24;P=0.04), and D-dimers (r=+0.33,P=0.004). Smoke influenced APAO values (odds ratio: 1.80; confidence interval 95%: 1.05–3.30), as well as diabetes during pregnancy (r=+0.42,P=0.0002). Maternal height influenced neonatal APAO (r=+0.47,P=0.00003). Multiple regression analysis outlined neonatal D-dimers as still significantly related to neonatal APAO values.Conclusions. Many maternal and neonatal characteristics could influence aorta structures. Neonatal D-dimers are independently related to APAO.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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