Hemostatic Parameters according to Renal Function and Time after Transplantation in Brazilian Renal Transplanted Patients

Author:

Mota Ana Paula Lucas1,Alpoim Patrícia Nessralla1,Figueiredo Roberta Carvalho de2,Simões e Silva Ana Cristina3,Braga Gomes Karina1ORCID,Dusse Luci Maria SantAna1

Affiliation:

1. Departamento de Analises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270901 Belo Horizonte, MG, Brazil

2. Departamento de Ciências da Saúde, Faculdade de Farmácia, Universidade Federal de São João del-Rei, 35501296 Divinópolis, MG, Brazil

3. Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas Gerais, 30130100 Belo Horizonte, MG, Brazil

Abstract

Kidney transplantation is the key for patients with end-stage renal disease, improving quality of life and longer survival. However, kidney transplant triggers an intense inflammatory response and alters the hemostatic system, but the pathophysiological mechanisms of these changes are not completely understood. The aim of this cross-sectional cohort study was to investigate hemostatic biomarkers in Brazilian renal transplanted patients according to renal function and time after transplantation. A total of 159 renal transplanted patients were enrolled and D-Dimer (D-Di), Thrombomodulin (TM), von Willebrand Factor (VWF), and ADAMTS13 plasma levels were assessed by ELISA. An increase of D-Di was observed in patients with higher levels of creatinine. ADAMTS13 levels were associated with creatinine plasma levels and D-Di levels with Glomerular Filtration Rate. These results suggested that D-Di and ADAMTS13 can be promising markers to estimate renal function. ADAMTS13 should be investigated throughout the posttransplant time to clarify the participation of this enzyme in glomerular filtration and acceptance or rejection of the graft in Brazilian transplanted patients.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

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