Fatigue and Sleep-Disordered Breathing in Multiple Sclerosis: A Clinically Relevant Association?

Author:

Kallweit Ulf12,Baumann Christian R.1,Harzheim Michael2,Hidalgo Hildegard2,Pöhlau Dieter2,Bassetti Claudio L.3,Linnebank Michael1,Valko Philipp O.1

Affiliation:

1. Department of Neurology, University Hospital Zurich, Frauenklinikstraße 26, 8091 Zurich, Switzerland

2. Department of Neurology, Kamillus-Klinik, Hospitalstrasse 6, 53567 Asbach, Germany

3. Department of Neurology, University of Bern, Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland

Abstract

Background. Fatigue in patients with multiple sclerosis (MS) is highly prevalent and severely impacts quality of life. Recent studies suggested that sleep-disordered breathing (SDB) significantly contributes to fatigue in MS.Study Objective. To evaluate the importance of routine respirography in MS patients with severe fatigue and to explore the effects of treatment with continuous positive airway pressure (CPAP).Patients and Methods. We prospectively assessed the presence of severe fatigue, as defined by a score of ≥5.0 on the Fatigue Severity Scale (FSS), in 258 consecutive MS patients. Ninety-seven patients (38%) suffered from severe fatigue, whereof 69 underwent overnight respirography.Results. We diagnosed SDB in 28 patients (41%). Male sex was the only independent associate of SDB severity (P=0.003). CPAP therapy in 6 patients was associated with a significant reduction of FSS scores (5.8±0.5versus4.8±0.6,P=0.04), but the scores remained pathological (≥4.0) in all patients.Conclusion. Respirography in MS patients with severe fatigue should be considered in daily medical practice, because SDB frequency is high and CPAP therapy reduces fatigue severity. However, future work is needed to understand the real impact of CPAP therapy on quality of life in this patient group.

Publisher

Hindawi Limited

Subject

Clinical Neurology

Cited by 29 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Fatigue and Sleepiness in Multiple Sclerosis and Their Response to Short‐Term Treatment With Modafinil;Acta Neurologica Scandinavica;2024-01

2. Sleep disturbance and fatigue in multiple sclerosis: A systematic review and meta-analysis;Multiple Sclerosis Journal - Experimental, Translational and Clinical;2023-07

3. The relationship between sleep quality and gait in people with multiple sclerosis: A pilot study;Hong Kong Physiotherapy Journal;2023-05-19

4. Sleep and Wake Disturbances;Fatigue in Multiple Sclerosis;2023

5. Chapitre 8. Fatigue, sommeil et sclérose en plaques;Sommeil, fatigue, troubles du sommeil et troubles cognitifs;2021-09-09

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