NLRP3 Inflammasome and Inflammatory Diseases-Reference-Cited by-同舟云学术

NLRP3 Inflammasome and Inflammatory Diseases

Published:2020-02-18 Issue: Volume:2020 Page:1-11
ISSN:1942-0900
Container-title:Oxidative Medicine and Cellular Longevity
language:en
Short-container-title:Oxidative Medicine and Cellular Longevity

Author:

Wang Zheng¹^ORCID,Zhang Simei¹^ORCID,Xiao Ying¹^ORCID,Zhang Wunai¹^ORCID,Wu Shuai¹^ORCID,Qin Tao¹^ORCID,Yue Yangyang¹^ORCID,Qian Weikun¹^ORCID,Li Li²^ORCID

Affiliation:

1. Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, China

2. Department of Ophthalmology, First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, China

Abstract

Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its proinflammatory role in inflammatory diseases, interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases will be summarized.

Funder

Science and Technology Innovation

Publisher

Hindawi Limited

Subject

Cell Biology,Aging,General Medicine,Biochemistry

Link

http://downloads.hindawi.com/journals/omcl/2020/4063562.pdf

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