Overview of Alzheimer’s Disease and Some Therapeutic Approaches Targeting Aβby Using Several Synthetic and Herbal Compounds-Reference-Cited by-同舟云学术

Overview of Alzheimer’s Disease and Some Therapeutic Approaches Targeting Aβby Using Several Synthetic and Herbal Compounds

Published:2016 Issue: Volume:2016 Page:1-22
ISSN:1942-0900
Container-title:Oxidative Medicine and Cellular Longevity
language:en
Short-container-title:Oxidative Medicine and Cellular Longevity

Author:

Singh Sandeep Kumar¹,Srivastav Saurabh¹,Yadav Amarish Kumar¹,Srikrishna Saripella¹,Perry George²

Affiliation:

1. Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India

2. Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA

Abstract

Alzheimer’s disease (AD) is a complex age-related neurodegenerative disease. In this review, we carefully detail amyloid-βmetabolism and its role in AD. We also consider the various genetic animal models used to evaluate therapeutics. Finally, we consider the role of synthetic and plant-based compounds in therapeutics.

Funder

Indian Council of Medical Research

Publisher

Hindawi Limited

Subject

Cell Biology,Ageing,General Medicine,Biochemistry

Link

http://downloads.hindawi.com/journals/omcl/2016/7361613.pdf

Reference210 articles.

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2. Alzheimer Disease in the US Population

3. Dementia in Kerala, South India: prevalence and influence of age, education and gender