Synthesis and Biological Evaluation of 4-(3-Hydroxy-benzofuran-2-yl)coumarins-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of 4-(3-Hydroxy-benzofuran-2-yl)coumarins

Published:2014-03-27 Issue: Volume:2014 Page:1-7
ISSN:2090-200X
Container-title:Organic Chemistry International
language:en
Short-container-title:Organic Chemistry International

Author:

Boregowda Puttaraju¹,Kalegowda Shivashankar¹,Rasal Vijaykumar Pandurang²,Eluru Jagadeeshreddy²,Koyye Ebenezer²

Affiliation:

1. P.G. Department of Chemistry, Central College Campus, Bangalore University, Bangalore, Karnataka 560 001, India

2. Department of Pharmacology, K.L.E. University’s College of Pharmacy, Belgaum, Karnataka 590 010, India

Abstract

Various 4-bromomethylcoumarins (1a-k) were reacted with methyl salicylate to yield 2-(2-oxo-2H-chromen-4-ylmethoxy)-benzoic acid methyl esters (2a-k). Formations of (3a-k) were achieved by using DBU under microwave irradiation. Structures of all the compounds were established on the basis of their spectral data. All the compounds were tested in vitro for their antimicrobial activity and cell cytotoxicity. All the tested compounds (2b-k) and (3a-k) were shown to be better activity against Staphylococcus aureus than the standard Ciprofloxacin. The compound (3k) (R = 6-OMe) was found to be more potent cytotoxic than the standard 5-fluorouracil.

Funder

Council of Scientific and Industrial Research, India

Publisher

Hindawi Limited

Subject

General Earth and Planetary Sciences,General Engineering,General Environmental Science

Link

http://downloads.hindawi.com/archive/2014/297586.pdf

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