Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies

Author:

Yuan Yuze1,Ran Nan1ORCID,Xiong Lingxin12ORCID,Wang Guoqiang1,Guan Xuewa1,Wang Ziyan1,Guo Yingqiao1,Pang Zhiqiang1,Fang Keyong1,Lu Junying13,Zhang Chao1,Zheng Ruipeng14,Zheng Jingtong1ORCID,Ma Jie2ORCID,Wang Fang1ORCID

Affiliation:

1. Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China

2. School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China

3. Department of Intensive Care Unit, First Hospital of Jilin University, Changchun 130021, China

4. Department of Interventional Therapy, First Hospital of Jilin University, Changchun 130021, China

Abstract

Obesity, one of the most severe public health problems of the 21st century, is a common metabolic syndrome due to excess body fat. The incidence and severity of obesity-related asthma have undergone a dramatic increase. Because obesity-related asthma is poorly controlled using conventional therapies, alternative and complementary therapies are urgently needed. Lipid metabolism may be abnormal in obesity-related asthma, and immune modulation therapies need to be investigated. Herein, we describe the immune regulators of lipid metabolism in obesity as well as the interplay of obesity and asthma. These lay the foundations for targeted therapies in terms of direct and indirect immune regulators of lipid metabolism, which ultimately help provide effective control of obesity-related asthma with a feasible treatment strategy.

Funder

Fundamental Research Funds for the General Universities

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

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