Comparison of 18F-FDG, 18F-Fluoroacetate, and 18F-FEPPA for Imaging Liver Fibrosis in a Bile Duct-Ligated Rat Model

Author:

Wu Chun-Yi1,Hsieh Hsin-Hua1,Chu Pei-An2,Hong Wen-Hsiang1,Chang Ting-Yu1,Hsu Chia-Fang2,Lin Siao-Ting2,Su Po-Hsun2,Peng Shin-Lei2ORCID

Affiliation:

1. Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan

2. Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 404, Taiwan

Abstract

Developing sensitive diagnostic methods for a longitudinal evaluation of the status of liver fibrosis is a priority. This study is aimed at assessing the significance of longitudinal positron emission tomography (PET) imaging with 18F-labeling tracers for assessing liver fibrosis in a rat model with bile duct ligation (BDL). Twenty-one 6-week-old Sprague-Dawley male rats were used in this study. Longitudinal PET images using [18F]N-2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide ([18F]FEPPA) ( n = 3 ), [18F]fluoroacetate ([18F]FAc) ( n = 3 ), and 18F-fluoro-2-deoxy-D-glucose ([18F]FDG) ( n = 3 ) were obtained at 0, 1, and 2 weeks after BDL. Biochemical assays, histological assays, immunohistochemical staining assays, and next generation sequencing analyses were also performed at 0 ( n = 3 ), 1 ( n = 3 ), 2 ( n = 3 ), and 3 ( n = 3 ) weeks after BDL, which demonstrated the severe damage in rat livers after BDL. Regarding [18F]FEPPA and [18F]FDG, there was a significantly higher uptake in the liver after BDL (both P < 0.05 ), which lasted until week 2. However, the uptake of [18F]FAc in the liver was not significantly different before and after BDL ( P = 0.28 ). Collectively, both [18F]FEPPA and [18F]FDG can serve as sensitive probes for detecting the liver fibrosis. However, [18F]FAc is not recommended to diagnose liver fibrosis.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Hindawi Limited

Subject

Condensed Matter Physics,Radiology, Nuclear Medicine and imaging,Biomedical Engineering,Molecular Medicine,Biotechnology

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