A New Approach for the Diagnosis of Systemic and Oral Diseases Based on Salivary Biomolecules

Author:

Roi Alexandra1ORCID,Rusu Laura C.1ORCID,Roi Ciprian I.2,Luca Ruxandra E.3,Boia Simina4,Munteanu Roxana I.3

Affiliation:

1. Department of Oral Pathology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania

2. Department of Anaesthesiology and Oral Surgery, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania

3. Department of Oral Rehabilitation and Dental Emergencies, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania

4. Department of Periodontology, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania

Abstract

Early diagnosis represents the target of contemporary medicine and has an important role in the prognosis and further treatment. Saliva is a biofluid that generated a high interest among researchers due to its multiple advantages over other body fluids. The multitude of components that can act as biomarkers influenced the existing technologies to develop protocols that could allow saliva to become the new noninvasive diagnostic method. Saliva as a diagnostic tool can bring substantial addition to the diagnostic armamentarium, providing important information about oral and general health. The diagnostic applications of saliva extended and had a rapid evolution due to the advancement in salivaomics. The present review summarizes the latest researches in saliva-related studies and explores the information and correlations that saliva can offer regarding the systemic and oral diseases, highlighting its great potential of diagnosis. It is expected that in the future specific guidelines and results regarding the salivary diagnostics are to be available, together with high-sensitivity and specificity tests for multiple systemic and oral diseases.

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

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