Comparison of Intravenous Dexmedetomidine versus Esmolol for Attenuation of Hemodynamic Response to Tracheal Intubation after Rapid Sequence Induction: A Systematic Review and Meta-Analysis

Author:

Li Zhao1ORCID,Xu Li2ORCID,Zheng Jinwei3ORCID,Wang Qingxiu1ORCID

Affiliation:

1. Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China

2. Department of Anesthesiology, The First People’s Hospital of Changde, Changde 415000, China

3. Department of Anesthesiology, Ningbo No. 2 Hospital, Ningbo 315000, China

Abstract

The present study aims to investigate whether intravenous dexmedetomidine shows superiority to esmolol for hemodynamic response to tracheal intubation after rapid sequence induction. In the present meta-analysis, PubMed, EMBASE, and the Cochrane Library were searched for trials comparing dexmedetomidine with esmolol for the attenuation of the hemodynamic response to intubation. Ten trials were selected in the present meta-analysis. Compared to esmolol, the use of dexmedetomidine maintains stable heart rates (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) at 1 min, 3 min, and 5 min after tracheal intubation. Dexmedetomidine causes less hemodynamic response to tracheal intubation after rapid sequence induction compared with esmolol.

Funder

Important Weak Subject Construction

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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