Correlation Study between Levels of Gastrin, Serum IGF-1, and GHBP and Growth and Development in Children with Short Stature Based on Big Data Analysis

Abstract

Objective. To analyze the correlation between the levels of gastrin, serum IGF-1, and GHBP and growth and development in children with short stature (SS) using the big data. Methods. By means of retrospective analysis, the clinical data of 42 children with SS admitted to our hospital from October 2020 to October 2021 were selected as the study group, while 30 children with the healthy physical examination results in the corresponding period were selected as the control group to measure the growth and development indices and the levels of gastrin, serum IGF-1, and GHBP. The Pearson correlation analysis was used for the relationship between the levels of gastrin, serum IGF-1, and GHBP and growth and development indices in children with SS, and the targeted intervention measures were formulated by the analysis of experimental data. Results. Compared with the study group, the height, weight, and bone mineral density (BMD) $Z$ -scores of children in the control group were obviously higher ( $P<0.001$ ). The levels of gastrin, serum IGF-1, and GHBP in the study group were markedly lower than those in the control group ( $P<0.05$ ). The Pearson correlation analysis showed that the gastrin, serum IGF-1, and GHBP of children were positively correlated with growth and development indices ( $P<0.001$ ). The levels of gastrin, serum IGF-1, and GHBP in children were distinctly improved after treatment ( $P<0.05$ ). Conclusion. The gastrin, serum IGF-1, and GHBP are closely related to the SS, and the effective clinical intervention can better improve the above indicators of children to promote their growth and development.