t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature-Reference-Cited by-同舟云学术

t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature

Published:2013 Issue: Volume:2013 Page:1-4
ISSN:2090-6560
Container-title:Case Reports in Hematology
language:en
Short-container-title:Case Reports in Hematology

Author:

Minson Katherine A.¹,Prasad Pinki¹²,Vear Susan¹²,Borinstein Scott¹²,Ho Richard¹²,Domm Jennifer¹²,Frangoul Haydar¹²

Affiliation:

1. Department of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN 37232, USA

2. Division of Pediatric Hematology/Oncology, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN 37232, USA

Abstract

Several cytogenetic abnormalities identified in patients with childhood acute lymphocytic leukemia (ALL) have been associated with a poor prognosis. There are several case reports in the literature describing t(17;19) in children with ALL. This translocation has been associated with hypercalcemia, coagulopathy, and poor outcome. We present three cases of ALL with t(17;19) treated at our institution and review the outcome of children reported in the medical literature.

Publisher

Hindawi Limited

Subject

Cell Biology,Developmental Biology,Embryology,Anatomy

Link

http://downloads.hindawi.com/journals/crihem/2013/563291.pdf

Reference14 articles.

1. Acute lymphoblastic leukaemia

2. Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

3. Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis

4. Two types of genomic rearrangements create alternative E2A-HLF fusion proteins in t(17;19)-ALL

5. Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19

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