Immune Regulation and Antitumor Effect of TIM-1-Reference-Cited by-同舟云学术

Immune Regulation and Antitumor Effect of TIM-1

Published:2016 Issue: Volume:2016 Page:1-6
ISSN:2314-8861
Container-title:Journal of Immunology Research
language:en
Short-container-title:Journal of Immunology Research

Author:

Du Peng¹²³,Xiong Ruihua¹²⁴,Li Xiaodong¹²,Jiang Jingting¹²

Affiliation:

1. Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China

2. Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China

3. The Second People’s Hospital of Gansu Province, Lanzhou, Gansu 730000, China

4. Department of Oncology, The 181st Hospital of PLA, Guilin, Guangxi 541002, China

Abstract

T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1.

Funder

National Key Technology R&D Program

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

Link

http://downloads.hindawi.com/journals/jir/2016/8605134.pdf

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