Antimycobacterial Activity of Some Synthesized Fluorinated Benzothiazolo Imidazole Compounds

Abstract

4-Fluoro-3-chloroanilline treated with potassium thiocyanate in presence of glacial acetic acid and bromine was converted into 2-amino-6-fluoro-7-chlorobenzothiazole, resulting into 2-amino benzothiazole. The synthesized compound in presence of 2-phenyl-4-benzylidine-5-oxazolinone refluxed in pyridine to obtain 2-(2-phenyl-4-benzylidenyl-5-oxo-imidazolin-1-yl amino)-6-fluoro-7-substituted(1,3)benzothiazoles. The above said compound was treated withortho, metaandpara nitroanillines, ortho, meta, parachloroanillines, morpholino, piperazine, diphenylamine in the presence of DMF to obtain different derivatives. Some compounds showed promising anti-microbial activity.