Expression of MAGE-A12 in Oral Squamous Cell Carcinoma

Author:

Mollaoglu Nur12,Vairaktaris Eleftherios3,Nkenke Emeka1,Neukam Friedrich W.1,Ries Jutta1

Affiliation:

1. Department of Oral and Maxillofacial Surgery, Friedrich- Alexander University of Erlangen/Nuremberg, Glückstrasse 11, 91054, Erlangen, Germany

2. Department of Oral and Maxillofacial Surgery, Gazi University, School of Dentistry, Emek 8.Cadde, 82.sokak, No:4, 06510, Ankara, Turkey

3. Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Attikon Hospital, Rimini 1, GR 12462, Greece

Abstract

Melanoma associated-A antigens (MAGE-A) are silent in normal tissues except testis. However, they are activated in a variety of different tumors. Thus, their expression is highly specific to cancer cells. Reverse transcription-nested polymerase chain reaction (RT-nPCR) is a highly sensitive technique that has been used successfully for the detection ofMAGE genes in tissue samples. The aim of the study is to analyze the expression rate of MAGE-A12 in oral squamous cell carcinoma (OSCC) using a high sensitive RT-nPCR. Total of 57 tissue samples obtained from patients with OSCC and 20 normal oral mucosal (NOM) probes of otherwise healthy volunteers were included to this study. No expression of MAGE-A12 was observed in the non-neoplastic NOM tissues. MAGE-A12 was expressed in 49.1% of the investigated tumor samples. The correlation between malignant lesion and MAGE-A12 detection was significant (p < 0.001). It is concluded that results of this study may indicate MAGE-A12 as a useful additional diagnostic marker especially for the early detection of OSCC distinguishing neoplastic transformation and detection of occult and/or rare disseminated cancer cells. In addition, MAGE-A12 expression in OSCC may also determine a new immunotherapeutic target and might be warranted to develop vaccine for OSCC.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Hindawi Limited

Subject

Biochemistry, medical,Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

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