Hypolipidemic Activity ofEryngium carlinaeon Streptozotocin-Induced Diabetic Rats

Abstract

Diabetes mellitus (DM) is a significant risk factor for the development of cardiovascular complications. This study was undertaken to investigate the effect of chronic administration of ethanolic extract ofEryngium carlinaeon glucose, creatinine, uric acid, total cholesterol, and triglycerides levels in serum of streptozotocin- (STZ-) induced diabetic rats. Triglycerides, total cholesterol, and uric acid levels increased in serum from diabetic rats. The treatment withE. carlinaeprevented these changes. The administration ofE. carlinaeextract reduced the levels of creatinine, uric acid, total cholesterol, and triglycerides. Thus administration ofE. carlinaeis able to reduce hyperlipidemia related to the cardiovascular risk in diabetes mellitus.