A Meta-Analysis of the Influence of Tumor Necrosis Factor-α-308 Gene Polymorphism on Liver Cirrhosis

Abstract

Cirrhosis is an active hepatic inflammation process of the liver considered as the serious phase of different liver injuries. Epidemiological studies have evaluated the possible association between TNF-α-308G/A gene polymorphism and liver cirrhosis. In this study, we have furthered the study to assess the exact association of TNF-α-308G/A gene polymorphism with liver cirrhosis susceptibility by integrating all available data. Eligible case-control studies were carried out from the establishment of the project to September 2021. Published literature from multiple databases was retrieved, collected, and analyzed by two investigators independently. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for every study. Review Manager 5.2 and Stata 15.0 software were used for meta-analysis and stability was assessed by both subgroup analysis and sensitivity analysis. Begg’s funnel plot and Egger’s regression across the studies were also explored. We examined 22 case-control studies with 2683 cirrhosis patients and 2905 normal controls in four genetic models (GA vs. GG: OR = 0.95, 95%CI: (0.70, 1.30); AA vs. GG: OR = 1.11, 95% CI: (0.66, 1.85), GA + AA vs. GG: OR = 1.00, 95% CI: (0.73, 1.37); AA vs. GA + GG: OR = 1.07, 95%CI: (0.70,1.63)). TNF-α-308G/A gene polymorphism was relatively independent, and the results did not show a significant difference between the two groups. In the subgroup analysis by etiological classification of liver cirrhosis, cirrhosis after HCV infection was positively associated with the risk of TNF-α-308G/A polymorphism (AA vs. GG: OR = 3.02, 95% CI: (1.15, 7.88), AA vs. GA + GG: OR = 2.68, 95% CI: (1.04, 6.95)). The meta-analysis showed TNF-α-308G/A gene polymorphism might not have affected susceptibility for liver cirrhosis. Nevertheless, further and well-designed studies were needed to confirm the findings.