The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue-Reference-Cited by-同舟云学术

The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue

Published:2013 Issue: Volume:2013 Page:1-28
ISSN:1687-8337
Container-title:International Journal of Endocrinology
language:en
Short-container-title:International Journal of Endocrinology

Author:

Sakurai Takuya¹,Ogasawara Junetsu¹,Kizaki Takako¹,Sato Shogo¹^ORCID,Ishibashi Yoshinaga¹,Takahashi Motoko²,Kobayashi Osamu³,Oh-ishi Shuji⁴^ORCID,Nagasawa Junichi⁵,Takahashi Kazuto⁶,Ishida Hitoshi⁶,Izawa Tetsuya⁷^ORCID,Ohno Hideki¹

Affiliation:

1. Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan

2. Department of Biochemistry, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-ku, Sapporo, Hokkaido 060-8556, Japan

3. Department of Nursing, Kyorin University, Faculty of Health Science, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan

4. Department of Respiratory Medicine, Hachioji Medical Center, Tokyo Medical University, 1163 Tatemachi, Hachioji, Tokyo 193-0998, Japan

5. Department of Applied Physics and Chemistry, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan

6. Third Department of Internal Medicine, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan

7. Department of Sports Biochemistry, Faculty of Health and Sport Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan

Abstract

Obesity is recognized as a risk factor for lifestyle-related diseases such as type 2 diabetes and cardiovascular disease. White adipose tissue (WAT) is not only a static storage site for energy; it is also a dynamic tissue that is actively involved in metabolic reactions and produces humoral factors, such as leptin and adiponectin, which are collectively referred to as adipokines. Additionally, because there is much evidence that obesity-induced inflammatory changes in WAT, which is caused by dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-αand monocyte chemoattractant protein 1, contribute to the development of insulin resistance, WAT has attracted special attention as an organ that causes diabetes and other lifestyle-related diseases. Exercise training (TR) not only leads to a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the inflammation-related adipokines in WAT. Therefore, TR is widely used as a tool for preventing and improving lifestyle-related diseases. This review outlines the impact of TR on the expression and secretory response of adipokines in WAT.

Funder

Ministry of Education, Culture, Sport, Science, and Technology of Japan

Publisher

Hindawi Limited

Subject

Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

Link

http://downloads.hindawi.com/journals/ije/2013/801743.pdf

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