Biosensing Technologies forMycobacterium tuberculosisDetection: Status and New Developments

Abstract

Biosensing technologies promise to improveMycobacterium tuberculosis(M. tuberculosis) detection and management in clinical diagnosis, food analysis, bioprocess, and environmental monitoring. A variety of portable, rapid, and sensitive biosensors with immediate “on-the-spot” interpretation have been developed forM. tuberculosisdetection based on different biological elements recognition systems and basic signal transducer principles. Here, we present a synopsis of current developments of biosensing technologies forM. tuberculosisdetection, which are classified on the basis of basic signal transducer principles, including piezoelectric quartz crystal biosensors, electrochemical biosensors, and magnetoelastic biosensors. Special attention is paid to the methods for improving the framework and analytical parameters of the biosensors, including sensitivity and analysis time as well as automation of analysis procedures. Challenges and perspectives of biosensing technologies development forM. tuberculosisdetection are also discussed in the final part of this paper.