Anticancer Effect of Puerarin on Ovarian Cancer Progression Contributes to the Tumor Suppressor Gene Expression and Gut Microbiota Modulation

Author:

Ye Yongju1ORCID,Gao Yang1ORCID,Fang Yuan1ORCID,Xu Lixia2ORCID,He Fule3ORCID

Affiliation:

1. Department of Gynaecology, Lishui Hospital of Traditional Chinese Medicine, Lishui City, 323000 Zhejiang Province, China

2. Clinical laboratory, Lishui Hospital of Traditional Chinese Medicine, Lishui City, 323000 Zhejiang Province, China

3. Zhejiang Chinese Medicine Museum, Zhejiang Chinese Medical University, Hangzhou City, 310053 Zhejiang Province, China

Abstract

Ovarian cancer (OC) causes more deaths than any other cancer of the female reproductive system due to its late presentation and malignant nature. Although significant progress has been made in the diagnosis and treatment of OC over the last decade, chemotherapeutic drug resistance and cancer recurrence remain serious challenges in OC management. In the field of cancer therapy, traditional Chinese herbal medicines and their active compounds have been widely reported to have favorable therapeutic effects on cancer. Recent studies have also revealed the protective effect of puerarin in cancer, but the exact role and underlying mechanism of puerarin in OC remain unclear. Here, we established in vivo and in vitro OC models to evaluate the anticancer effect of puerarin. It was found that puerarin significantly inhibited OC cell viability and proliferation and induced cell apoptosis. In OC model mice, puerarin treatment suppressed tumor formation and modulated the gut microbiome. In addition, the expression of tumor suppressor genes was activated by puerarin in vitro and in vivo. These findings add to the existing knowledge on the usefulness of herbal active ingredients for the prevention and treatment of OC and provide a new perspective regarding the therapeutic potential of puerarin in cancer.

Funder

Zhejiang Provincial Basic Public Welfare Research Project, China

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

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