Efficacy of Pharmaceutical Care in Patients with Type 2 Diabetes Mellitus and Hypertension: A Randomized Controlled Trial

Author:

Wang Weibo1ORCID,Geng Lijuan2ORCID,Sun Chenjing1ORCID,Li Hui3ORCID,Wang Jinying1ORCID

Affiliation:

1. Department of Pharmacy, Dongying People’s Hospital, Dongying, China

2. Department of Pharmacy, The Second People’s Hospital of Dongying, Dongying, China

3. Department of Quality Management, Dongying People’s Hospital, Dongying, China

Abstract

Background. The rates of treatment adherence and treat-to-target rates of blood pressure and blood glucose-related indexes in patients with hypertension and type 2 diabetes mellitus (T2DM) are associated with prognosis. This study aimed to investigate the efficacy of pharmaceutical care postdischarge for treatment adherence in hypertensive patients with type 2 diabetes mellitus (T2DM). Methods. This was a randomized controlled trial of patients with combined T2DM and hypertension treated between January and May 2018. Pharmaceutical care included free access to a clinical pharmacist, education material, a WeChat account for live discussion, and a telephone follow-up. The primary endpoint was the 3-month medication adherence. The secondary endpoints included the achieving levels of target rates and values of fasting plasma glucose (FPG), 2 h postprandial glucose (2hPG), and hemoglobin A1c (HbA1c) and the rates of reaching the achieving target rate of blood pressure target <130/80. Results. In 80 participants, the 3-month medication adherence was higher in the pharmaceutical care group than the routine group (90.0% vs. 52.5%, P < 0.001 ). In terms of FPG, 2hPG, and HbA1c, there were also significant differences between the pharmaceutical care and routine groups (FPG, 6.50 (6.00, 7.18) vs. 7.00 (6.83, 7.78) mmol/L, P = 0.004 ; 2hPG, 8.45 (7.45, 9.28) vs. 9.35 (8.23, 10.15), P = 0.007 ; HbA1c, 6.5% (6.3%, 7.0%) vs. 7.0% (6.5%, 7.4%), P = 0.007 ). The achieving target rate of reaching the blood pressure target in the pharmaceutical care group (92.5%) was significantly higher than that in the routine group (62.5%; P < 0.05 ). Conclusion. The postdischarge pharmaceutical care program in patients with T2DM and hypertension improves medication adherence.

Funder

Chinese Pharmaceutical Association

Publisher

Hindawi Limited

Subject

General Medicine

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