The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism

Author:

Yang Fan1,Song Yanli2,Song Haoming3,Zheng Weiping1,Wang Lemin3ORCID

Affiliation:

1. Department of Clinical Laboratory, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China

2. Department of Internal Emergency, Tongji Hospital, Tongji University School of Medicine, Shanghai, 20006, China

3. Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China

Abstract

Objective. To investigate the diagnostic value of circulating integrins β1, 2, and 3 in venous thrombosis (VTE). Materials and Methods. A total of 474 VTE patients and 306 patients with nonhigh risk for VTE as the control group were studied. Levels of adhering integrins β1, 2, and 3 were detected by flow cytometry. Levels of circulating integrins β1, 2, and 3 in serum were measured by enzyme-linked immunosorbent assay. Results. We found that integrins β1, 2, and 3 were expressed highly both in serum and on the surface of leukocytes and platelets in venous thromboembolism. The levels of circulating integrins β1, 2, and 3 are positively correlated with adhering integrins. It showed excellent clinical diagnostic performance of circulating integrins β1, 2, and 3 in venous thromboembolism. Conclusions. Integrin subunit β can be used as a diagnostic marker with high sensitivity and specificity for venous thromboembolism.

Funder

Natural Science Foundation of Xinjiang

Publisher

Hindawi Limited

Subject

Applied Mathematics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Modeling and Simulation,General Medicine

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