Affiliation:
1. Department of Pharmacy, Kantipur Academy of Health Sciences, Kathmandu 44600, Nepal
2. Department of Quality Control, Times Pharmaceuticals Private Limited, Chitwan 44200, Nepal
3. Department of Research and Development, Asian Pharmaceuticals Private Limited, Rupandehi 32900, Nepal
4. Department of Research and Development, Deurali Janata Pharmaceutical Private Limited, Kathmandu 44600, Nepal
5. Department of Pharmacy, Crimson College of Technology, Affiliated with Pokhara University, Devinagar-11, Butwal 32900, Nepal
Abstract
Ebastine is a long-acting, nonsedating, second-generation antihistaminic drug that prevents histamine action, mainly in immediate hypersensitivity. This project was aimed to formulate and characterize orodispersible tablets of ebastine, utilizing different proportions of three disintegrants, namely crospovidone, sodium starch glycolate, and coprocessed superdisintegrant. Initially, fifteen trial batches of ebastine orodispersible tablets were outlined using the central composite design of Minitab software. The tablets were formulated by the direct compression method. The compressed tablets were then evaluated for precompression and postcompression physicochemical parameters, such as angle of repose, Carr’s index, Hausner’s ratio, hardness, thickness, weight variation, drug content, friability, wetting time, disintegration time, dispersion time, and water absorption ratio. The in vitro dissolution test was conducted according to Indian Pharmacopeia 2018, with the help of the rotating paddle method using 0.5% w/v sodium lauryl sulfate buffer in 0.1 N HCl. For the optimized batch (8th batch), all the physicochemical parameters like angle of repose (33.77°), Carr’s index (19.34%), Hausner’s ratio (1.24), weight variation (202.5 mg), hardness (4.3 kg/cm2), friability (0.44%), thickness (3.16 mm), dissolution (95.78%), and drug content (101.67%) were within the acceptable limit as per Indian Pharmacopeia 2018. The wetting time, disintegration time, dispersion time, and water absorption ratio were reported to be 25.1 seconds, 16.0 seconds, 38.6 seconds, and 91.92%, respectively. Hence, the results suggested that orodispersible tablets of ebastine can be formulated. Furthermore, the mixing of crospovidone, sodium starch glycolate, and coprocessed super disintegrants can result in excellent desirable properties in the orodispersible tablet.
Subject
General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference44 articles.
1. Mouth dissolving tablets: a new venture in modern formulation technology;A. Gandhi;The Pharma Innovation,2012
2. Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac
3. Formulation and evaluation of fast dissolving tablets of montelukast sodium using co-processed superdisintegrants;B. Shravani;International Journal of Drug Development & Research,2014
4. Review on: fast dissolving tablet;M. P. Ratnaparkhi;Journal of Pharmacy Research,2009
5. Design of fast dissolving granisetron HCL tablets using novel coprocessed superdisintegrants;D. Nagendrakumar;International Journal of Pharmaceutical Sciences Review and Research,2010